Vincent storme4/30/2023 ![]() ![]() There is controversy regarding whether or not these different histological types have any bearing on prognosis. Adenocarcinoma and adenosquamous cell carcinoma represent 10–15%, and other or unspecified histology represent the remaining 10–15%. Squamous cell carcinoma (SCC) is the predominant histological type accounting for three-fourths of all cervical cancers. Increased incidence of adenocarcinomas, their adverse prognosis, and the young age at diagnosis indicate the need to identify women who are at risk.Ĭancer of the cervix uteri is the second most common cancer (after breast cancer) and the third leading cancer mortality (after lung and breast cancer) among women worldwide. ![]() The incidental observation of increasing numbers of adenocarcinomas despite a general decline suggests the inefficiency of conventional screening for these tumors. Small cell carcinoma and adenocarcinomas were associated with poorer survival. Cause-specific mortality hazard ratios by histological type relatively to non-microinvasive squamous cell carcinoma were: microinvasive squamous cell carcinoma 0.28 (95% confidence interval: 0.20–0.39), carcinoma not otherwise specified 0.91 (0.79–1.04), non-mucinous adenocarcinoma 1.06 (0.98–1.15), adenosquamous carcinoma 1.35 (1.20–1.51), mucinous adenocarcinoma 1.52 (1.23–1.88), small cell carcinoma 1.94 (1.58–2.39). The histological types were jointly significant, P < 0.001. Statistically significant variables for both overall and cause-specific mortality were: age, year of diagnosis, race, stage, histology, grade, hysterectomy, radiotherapy, tumor size and nodal ratio. From 1973 to 2002, number of cases dropped from 1,100 new cases/year to 900/year, but adenocarcinomas and adenosquamous carcinoma increased from 100/year to 235/year. Registry area, age, marital status, race, year of diagnosis, tumor histology, grade, stage, tumor size, number of positive nodes, number of examined nodes, odds of nodal involvement, extent of surgery, and radiotherapy were evaluated in Cox models by stepwise selection using the Akaike Information Criteria. Only histologies with at least 100 cases were retained. Women under active follow-up for histologically confirmed primary invasive cervical cancer were selected from the United States Surveillance, Epidemiology, and End Results (SEER) 9-registries public use data 1973–2002. ![]() Histopathology is a cornerstone in the diagnosis of cervical cancer but the prognostic value is controversial. ![]()
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